أكتب الإجابة الصحيحة ؟ M.C.Q

A 62 year old man is found to have squamous cell carcinoma of the lung after being investigated for haemoptysis. 

Which one of the following would be a contraindication to surgical resection?
Available marks are shown in brackets

1 ) Finger clubbing
2 ) Hypercalcaemia
3 ) Hypertrophic pulmonary osteoarthropathy
4 ) Pleural effusion
5 ) Superior vena cava obstruction